NOVEL COLCHICINE DERIVATIVES, METHODS AND USES THE

专利名称：NOVEL COLCHICINE DERIVATIVES,

METHODS AND USES THEREOF

发明人：TUSZYNSKI, Jack,MANE, Jonathan Y.,HUZIL,

John Torin

申请号：EP10811047.9申请日：20100730公开号：EP2470499B1公开日：20190612

摘要：The invention relates to colchicine derivatives, methods and uses thereof fortreatment of cancer. In certain embodiments, the colchicine derivative comprises acompound of formula (I), wherein Z is O or S; R is selected fro H, a halo group, asubstituted or unsubstituted hydrocarbon group, or a substituted or unsubstitutedheterogeneous group; R and R are each independently selected from H, a halo group, asubstituted or unsubstituted hydrocarbon group, a substituted or unsubstituted

heterogeneous group, a substituted or unsubstituted carbocyclic group, a substituted orunsubstituted heterocyclic group, substituted or unsubstituted aromatic, or a substitutedor unsubstituted heteroaromatic; R is selected from H or a substituted or unsubstitutedhydrocarbon group, with the proviso that when R, R and R are methyl groups, R is not -COCH.

申请人：ALBERTA HEALTH SERVICES

地址：CA

国籍：CA

代理机构：Appleyard Lees IP LLP

更多信息请下载全文后查看