ECGPPG
The correlation analysis of the ECG and the PPG signal
林
呂林年
a
ECGPPG
b
ECGPPG
林老不論領了見勵益良老LabVIEW更老論利更利
連見論利樂
i
ECGPPG
ElectrocardiogramECG率異(Heart rate variability, HRV)神度(autonomic neural activity)來年療度量更易更便
論 (PhotoplethysmogramPPG) ECG流量ECG律異PPG易ECG不來療理
神ECG率PPGAM兩率理來兩來理量
(PPG)率異(HRV)(ECG)
ii
ECGPPG
Abstract
Electrocardiogram (ECG) is wildly used to assess the heart function in medical science. The heart rate variability (HRV) influences by many factors such as breathblood pressureexercisesleepdisease and drugs. It reflects the activities of autonomic nervous system in our body. However, with the population aging of the whole world, it will be a high requirement for us to use health care medical appliances at home. The equipments will be made smaller and handier than those before. It will be operated by people more easily within five years.
Relying on the superiority of the Photoplethysmogram (PPG), people can get more information about artery and blood stream volume than those about ECG. Applying correlation analysis with the heart rate variability of ECG, we hope to use the properties of non-incursiveeasy handlingand no materials consuming of PPG to replace the inadequate of ECG , and combine with the remote medical treatment monitor and home nursing in the future. It also helps us to realize the early periods diagnosis and prevention cardiovascular diseases. In the future, therefore, it is possible to combine and cooperative these two advantages and use it to measure physical signal.
Keyword: Photoplethysmogram(PPG)Heart rate variability(HRV)
Electrocardiogram(ECG)
iii
ECGPPG
錄
-------------------------------------------------------------------------------------------------i ------------------------------------------------------------------------------------------ii-----------------------------------------------------------------------------------------iii 錄-----------------------------------------------------------------------------------------------iv 錄--------------------------------------------------------------------------------------------vi 錄------------------------------------------------------------------------------------------viii 說-----------------------------------------------------------------------------------------ix ------------------------------------------------------------------------------------x
論
1.1 --------------------------------------------------------------------------------1 1.2 -----------------------------------------------------------------1
1.3-----------------------------------------------------------------------2
2.1 PPG-----------------------------------------------------------------------4 2.1.1 PPG理--------------------------------------------------------62.2()律神------------------------------------------------------------92.3律異-------------------------------------------------------------------102.4-------------------------------------------------------------------12
3.1 說-------------------------------------------------------------------------16
3.1.1Biopac MP30-----------------------------------163.1.2 -------------------------------------------------------------173.2-------------------------------------------------------------------------19
iv
ECGPPG
3.2.1PPG--------------------------------------------------------------19 3.2.2ECG-------------------------------------------------------------22
3.2.3 ECGPPG-------------------------------------------------25
4.1-------------------------------------------------------------------------27
4.2 -------------------------------------------------------------------------32 論來-------------------------------------------------------------------36參----------------------------------------------------------------------------------------37
v
ECGPPG
錄
2-1 PPG()---------------------------------------42-2 量PPG()------------------------------------52-3 PPG(藍)-------------------------------------------5 2-4()----------------------------------------62-5 2-62-7 2-8 PPG2-9 AM2-10 2-11 ECG3-13-2 3-4 PPG3-53-6 3-7 3-8 PPG3-9 PPG3-10 PPG3-11 R-R3-12 ECG3-13 ()----------------------------------6()----------------------------------------7()----------------------------------7連------------------------------------------------------------------7 BL-----------------------------------------------------------------8 律神--------------------------------------------------------10 -------------------------------------------------------------------------13Biopac MP30------------------------------------------------------------16量--------------------------------------------------------------------18----------------------------------------------------------------19AMBL------------------------------------------------------------------20AM--------------------------------------------------20PPI-----------------------------------------------------------21PPG率-------------------------------------------21-------------------------------------------------------------21PPI----------------------------------------------------22 率--------------------------------------------------------------------22-----------------------------------------------------------------------------23----------------------------------------------------------23 ECGR-R---------------------------------------------23
vi
ECGPPG
3-14ECGR-R率---------------------------243-15 ECGLFHF---------------------------------24 3-16 ECG-------------------------------------------------------------------243-17 ECGR-R-------------------------------------------------------------------253-18 ECG率-------------------------------------------------------------------253-19 流-----------------------------------------------------------------254-1 R-RPPI(1量)--------------------------------------------284-2 R-RPPI(1量)--------------------------------------------294-3 R-RPPI(1量)--------------------------------------------294-4 ECGPPG----------------------------------------------------------33
vii
ECGPPG
錄
1-1 ECGPPG-----------------------------------------------------------24-1 ECG量PPGAM-----------------------------------27 4-2 ECGPPG數-----------------------------------------------30 4-3 ECGPPG率數-------------------------------------------31
viii
ECGPPG
說
XA數VA
γXY=數
sXY=異數 sX=X sY=Y
ix
ECGPPG
A
Amplitude (AM) ------PPG參數
Autonomic neural activity ------神度 B
Baseline (BL) ------PPG參數 Baroreceptor ------
Biopac Student Lab (BSL) ------Biopac MP30 Biopac Student Lab Pro (BSL Pro) ------Biopac MP30 C
Correlation coefficient------數 E
Electrocardiogram (ECG) ------Electro surgery ------療 F
Frequency domain ------ H
Heart rate variability (HRV) ------率異High frequency (HF) ------
High frequency power (HFP) ------率 L
Low frequency (LF) -------
Low frequency power (LFP) ------率 N
Nucleus Ambiguu(NA) ------
x
ECGPPG
Normalized unit ------ P
Photoplethysmogram (PPG) ------
Pearson Product Moment correlation coefficient------數 Peak ------
Peak detect ------ P wave -------P Q
QRS complex ------QRS QT Interval ------QT Q wave ------Q R
R-R interval ------R-R S
Sinoatrial node (SA node) ------ Standard deviation (SD) ST segment -------ST T
T wave ------T
Total power (TP) ------率 Time domain ------ U
U wave ------UV V
Valley ------
Very low frequency(VLF) -------
xi
ECGPPG
論
1.1
來年療行療邏療年北療來年療行療度來便療[1]
(ECG)狀臨參[2]量量兩理來說不便(PPG)不量便度益療理來說PPG便
率留度率異率異(HRV)率異更率異率異神度(autonomic neural activity)年來[3]陸領率異切聯塞率異度不良PPG來流量率異
1.2
ECG量不便利PPG來ECG更便量ECGPPG
1
ECGPPG
錄流量PPG率異PPGECGPPGECG來量量不便
1-1ECGPPG
ECG PPG PPG不EMI
PPG不
路量便度
PPG省
臨
易5060Hz易路
量兩
易易量
易
易狀路理
1.3
理了率(Sinoatrial nodeSA node)SA node行律神神神神來神神率率異ECGRR(R-R interval)神(Nucleus AmbiguuNA)率降ECGRR神度率ECG
2
ECGPPG
率異[4,5]
1939年Burtion度連神PPG了
數年PPG神聯2001年Nitzan切神神PPG參數BL(Baseline)AM(Amplitude)理PPG度聯[6,10]
臨來神度不利HRV神度數行更易行HRV神度(high frequencyHF)(low frequencyLF)更神度年[4,5,19] 1 HF神度切LF神神
(Baroreceptor)度
LF/HF神神LF/(LF+HF)神度
SDNNNN異數(variance)HRV率pNN50神
PPG量神聯律異ECGPPGECGPPGECGPPGECG來PPG量量不便
3
ECGPPG
2.1 PPG
PPG利量理錄流量[6,7]若PPG量
PPG兩力流連量PPG2-1
2-1 PPG()[8]
力量PPG2-2
4
ECGPPG
2-2 量PPG()[8]
PPG兩藍[7]
2-3 PPG(藍)[8]
PPG了力PPG律神狀(度)不PPG
5
ECGPPG
不PPG數來兩[7,11]
2.1.1 PPG理
流連力力連連量理量利利度連
2-4LED2-5
2-4()[7]
2-5 ()[9]
6
ECGPPG
2-6LED度不離2-7度連2-8
2-6()[7]
2-7 ()[7]
2-8 PPG連[6]
PPG(Tissue)2-9參數AMBLAM理
7
ECGPPG
AMBL量BL兩(2-1)[10]
AM / BL=XA ×VA (2-1)
XA數
VA
BL
Min Max AM
2-9 AMBL[10]
BLAM
PPG利量量便易狀若度PPG度降不PPG參[6,7]
8
ECGPPG
2.2律神
律神來說律神
2-10泌來力律神[12,13]
神神滑流量行了神狀度力行[12,13]
理狀神律率律神[12,13]
神刺神刺神神理[12,13]
9
ECGPPG
2-10律神[17]
2.3 率異
率異量神年來律神神神神不率律神
率異都力神力神
神不狀塞糖尿老神降率異[12,13]
10
ECGPPG
率異兩律率律神率不異來律神率率降[13,14]
律異(time domain)(frequency domain)來(mean)(standard deviation SD)律異數(HRVI)利葉度率數度量[14]
律異0Hz0.5Hz數參略0.02~0.09Hz來力律神0.09~0.15Hz來力0.03Hz神率率率0.02Hz(very low frequencyVLF)律1/f神[14]
率率率率(total power , TP)率率(low frequency power , LFP)率(high frequency power , HFP)率神率神率神狀[14]
錄VLFLFHF率LFHF率不神率VLF 理PSD[14]
11
ECGPPG
VLFLFHF率(sec 2 /Hz)來LFPHFP(normalized unit)來(2-2)[14]
LF(HF)n.u=
LF(HF)power
×100% (2-2)
Totalpower−VLFpower
LFHF率神神行LF(HF)率率了率都參[14]
2.4ECG
利流理來
ECGECG流流金來錄錄良金錄ECG來了神狀[15]
ECG了神來律塞狀狀度loading ECG狀狀讀來[15]
12
ECGPPG
2-11 ECGP WaveQRS complexT U[18]
1 PP wave
P2.5mV0.06~0.10aVRaVF
2QRSQRS complex
QRS0.08~0.10QRS 30度100度
3Q wave
0.04度QRS25%
4STST segment
ST
5R-RR-R Interval
RR率
13
ECGPPG
率率不來率R-R 0.6~1.0
6QTQT Interval
QRST復QT率異率QTQTc(2-3)
QTc0.35~0.44 QT QTc = (2-3) QTc = 7TT wave
QRS5mmT率異0.10~0.25T0.5mV
8UU wave
來金不T5-25%[15]
R-RR-R1012()年異RR率率不來說2210率15795神神[16]
14
ECGPPG
神度降神率度神率[16]
15
ECGPPG
3.1說
PPG利量理錄量異量量PPG利Biopac MP30PPGLabVIEW
3.1.1 Biopac MP30
Biopac MP30量
Biopac理連不便量PPG不理
BiopacMP30MP30理8-PINserial port連兩狀3-1I/O device狀[19]
3-1Biopac MP30
16
ECGPPG
[19]
1連不不
2Biopac MP30連類
3益益
4不不
5易易行理
6Biopac Student Lab(BSL)Biopac Student Lab Pro(BSL Pro)兩BSL不類量BSL Pro量不
7量(.txt)(.jpg)便不
3.1.2
Biopac MP30CH1CH2不3-2狀
CH1連PPG量
17
ECGPPG
CH2連ECG
律神ECG[6]了PPG律神利ECG便ECGPPG
3-2量
臨
量來量利
ECG料PPGBLAMECG
ECG量理量
易
18
ECGPPG
量易錄
量不
3.2
LabVIEWBiopac 30理參數數
3.2.1 PPG
利BSL Pro量兩
3-3PPGAMAMPPG零BLBL
[18]
19
ECGPPG
3-4 PPGAMBL[11]
PPGPPGAMPPG利
LabVIEWpeak detectpeakvalleyAM3-5利LabVIEW3-6參狀AM0.48mV若AM
0.48mV神參[10]PPGPPGAM列AMPPGPPIPPGPPI率
3-5AM
20
ECGPPG
了PPG參數AMPPG
R-R(PPI)PPG率度利ECG
PPGLabVIEWINDEX 1列列PPI列3-6PPI
PPGPPI利立葉PPI率 3-7PPG率
3-8 PPG
21
ECGPPG
3-9 PPG數PPI
3-10 PPG率(Hz)
3.2.2 ECG
律神ECGECG兩ECG
1ECGR-R2ECGR-R率
3ECG率LFHF兩狀律神神
ECGQRSRRR-RR-R列立葉便00.4Hz率數兩LF0.04~0.15HzHF0.15~0.4Hz兩律神神神
22
ECGPPG
3-11 R-R[6]
3-12 ECG[6]
ECG
ECG
INDEX 1列列R-R列
3-13 ECGR-R
LabVIEW 23
ECGPPG
ECGR-R利立葉ECG率
3-14ECGR-R率
率ECG
LFHF
3-15 ECGLFHF
3-16 ECG
24
LFHF ECGPPG
3-17 ECGR-R數
3-18 ECG率(Hz)
3.2.3 ECGPPG
兩
ECGPPG兩R-R()ECGPPG兩率()
數兩數 3-19流
25
理ECGPPG料(R-R率)料理讀料數 ECGPPG
數來量兩數度裡XY數數(correlation coefficient)數數-1
+1+1XY句說落率-1XY句說落率若數零XY[4]
數(Pearson Product Moment correlation coefficient)(3-1)[4]
γXY=
sXY
(3-1)sXsY
γXY=數
sXY=異數 sX=X sY=Y
數不
xi−xyi−y離(3-2)[4]
γXY=
∑X
2i
∑XY−(∑X∑Y)n−(∑X)n∑Y−(∑Y)ii
i
i
2
2
i
i
i
2
(3-2)
n
26
ECGPPG
4.1
ECGPPGAM來ECGPPG來ECGPPG率ECGPPG
ECGPPGAM4-1
4-1 ECG量PPGAM年
狀
LF (ms 2)
AM (mV)
()(cm)(kg)
451.19 0.63728.35 1.101311.24 1.89517.62 0.74891.33 1.161741.10 1.75622.77 0.831033.45 1.373577.17 3.20121 女PM 1:00~3:00 16363
222 PM 1:00~3:00 17269
323 PM 1:00~3:00 17275
論
參狀AM0.48mV若AM0.48mV神參[10]見AM
27
ECGPPG
0.48mVECG0.04Hz~0.15Hz量神ECG0.04Hz~0.15Hz量狀量LFAM神PPGAM
論
1ECG若神參AM0.48mVPPG參數AMECG量LF(神量)度
2量LFAM
來ECGPPG
1狀量例
4-1 R-RPPI數(1量)
28
ECGPPG
4-2 R-RPPI數(1量)
4-3 R-RPPI(1量)
29
ECGPPG
ECGR-RPPGPPI數4-2
4-2 ECGR-RPPGPPI數年
狀
數
()(cm) (kg)
0.04999 0.12128 -0.09029 -0.00578
PM 1:00~3:00
0.05687 0.05689 0.01580 0.57547 0.08614
121 女163 63
222 172 69
323 172 75
論
1例R-RPPI數兩ECGPPG論
來ECGPPG率
數ECGPPG率數4-3
30
ECGPPG
4-3 ECGPPG率數年
狀
1
數
()(cm)(kg)
0.95549 0.99368 0.99994 0.99494 0.99999 0.99984 0.99797 0.99727 0.99999
21 女163 65
222 172 69 PM 1:00~3:00
323 172 75
論
ECGPPG率數ECGPPG度說ECGPPG率神量理ECGPPG率ECGPPG
列ECGPPG
1神ECG率量LFPPGAM
2ECGPPG兩量
理
3ECGPPG率理
31
ECGPPG
4.2
量來
1ECG神神ECG0.04Hz~0.15Hz量PPGAM0.48mV來神PPGAMPPG露理ECG
2ECG量流來量PPG律流ECGPPGR-R度
3ECG神量神量律異兩R-R度論量論ECGPPG率都
4ECGPPG
32
ECGPPG
4-4 ECGPPG1神ECG率量LFPPGAM AM理神滑流量了神狀度力神神不力神量量LFAM2ECGPPG兩量ECGPPG都兩 33ECGPPG
1PPG
ECG利來連PPG流流錄量度流度ECG量理PPG了流行數兩料不
2PPG量量不易
PPG數來理理理PPG了靈量若來數都PPG量不易流量不精
3ECGPPG率理
來ECGPPG來不X率數了Y率量PPG量來說ECGPPG來
量
量PPG不易更度更精列量
1數
數論
34
ECGPPG
度力都更理
2
PPG理靈度PPG降
3度
量切都PPG量
4
ECG離
ECGPPG更便利PPG狀率若離療(Electro surgery)量ECG不流量降量不PPGPPG便量ECG不略量PPG
35
ECGPPG
論來
PPGECG料兩率
PPG量
PPG
PPG理量量不易
PPG量量
讀
PPGECG臨來不PPGPPGLED流來率
療療[1]療理療行PPG量易PPGECG更ECG流量不PPG
HRV更ECG不PPGPPGECG臨
36
ECGPPG
參
[1]http://marketing.chinatimes.com/ItemDetailPage/MainContent/05MediaContent.aspx?MMMediaType=ec%5Fnews&offset=24&MMContentNoID=26574 [2]呂2001 [3]A. Vander, Human Physiology, WCB Mcgraw-Hill, 1998.
European Heart Journal Vol. 171996,3 [4]Standards of heart rate variability
塞率異度[5] 北
2005年952005
[6] 率PPG
論2005,6,28
[7] 利Plethysmography
論2004,6
[8]http://marketing.chinatimes.com/ItemDetailPage/MainContent/05MediaContent.aspx?MMMediaType=ec%5Fnews&offset=24&MMContentNoID=26574 [9]http://www.medis-de.com/en/ppg.html
[10]B. Khanokh, Y. Slovik, D. Landau, M. NitzanSympathetically induced
spontaneous fluctuations of the photoplethysmographic signalMedical & Biological Engineering & Computing2004
[11] 林 理參數
2004
[12] 利率異律神
論1998.6
[13] 率異立
論1996,6
37
ECGPPG
[14] 龍利率異度神
論2002,6
[15] 臨理2003,9 [16] 率理2000,9,15 [17] http://www.drguo.com/# (2-10律神)
[18] 利PPG神
2005,6
[19]率異數
2005,6
[20] Biopac system MP35 & MP30 specifications
38
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