(R)-Baclofen hydrochloride_63701-55-3_DataSheet_MedChemExpress

Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :(R)-Baclofen hydrochloride63701-55-3HY-17354A250.12C10H13Cl2NO2>98%Solubility:DMSOMechanisms: Pathways:Membrane Tranporter/Ion Channel; Target:GABA Receptor Pathways:Neuronal Signaling; Target:GABA Receptor Biological Activity:()ygy()py(R)-Baclofen hydrochloride is a derivative of gamma-aminobutyric acid (GABA) primarily used totreat spasticity and is in the early research stages for use for the treatment of alcoholism. Target: GABA Baclofen (brand names Kemstro, Lioresal, Liofen, Gablofen, Beklo and Baclosan) is a derivative ofgamma-aminobutyric acid (GABA). It is primarily used to treat spasticity and is in the early researchstages for use for the treatment of alcoholism. It is also used by compounding pharmacies in topicalpain creams as a muscle relaxant. It is an agonist for the GABAB receptors. Its beneficial effects in spasticity result from actions atspinal and supraspinal sites. Baclofen can also be used to treat hiccups, and has been shown toprevent rises in body temperature induced by the drug MDMA in rats.In addition, research hasshown baclofen to be effective in the treatment of a...References:[1]. Mezler M, et al. Cloning and functional expression of GABA(B) receptors from Drosophila. Eur JNeurosci. 2001 Feb;13(3):477-86. [2]DzitoyevaSetalGamma-aminobutyric[2]. Dzitoyeva S, et al. Gammaaminobutyric acid B receptor 1 mediates behavioracidBreceptor1mediatesbehavior-impairingimpairing actionsactionsof alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad SciU S A. 2003 Apr 29;100(9):5485-90. Epub 2003 Apr 11. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr