POTENT LNA OLIGONUCLEOTIDES FOR THE INHIBITION OF

专利名称：POTENT LNA OLIGONUCLEOTIDES FOR THE

INHIBITION OF HIF-1A

发明人：RASMUSSEN, Frank Winther,WESTERGAARD,

Majken,HANSEN, Henrik Frydenlund,THRUE,Charlotte Albæk

申请号：EP05800760.0申请日：20051109公开号：EP1833840B1公开日：20100804

摘要：The present disclosure relates to an LNA oligonucleotide consisting of asequence selected from the group consisting of 5'-(Tx GxGxcsasasasgscsastscscsTXGX T-3' and 5'-(GX )TXTXascstsgscscststscsTXTX A-3', wherein capital letters designate a beta-D-oxy-LNA nucleotide analogue, small letters designate a 2-deoxynucleotide, underlinedesignates either a beta-D-oxy-LNA nucleotide analogue or a 2-deoxynucleotide,subscript 's' designates a phosphorothioate link between neighbouring nucleotides/LNAnucleotide analogues, and subscript 'x' designates either a phosphorothioate link or aphosphorodiester link between neighbouring nucleotides/LNA nucleotide analogues, andwherein the sequence is optionally extended by up to five 2-deoxynucleotide units. TheLNA oligonucleotides are useful for modulating the expression of hypoxia-induciblefactor-la (HIF-1a), e.g. in the treatment of cancer diseases, inhibiting angiogenesis,inducing apoptosis, preventing cellular proliferation, or treating an angiogenic disease,e.g. diabetic retinopathy, macular degeneration (ARMD), psoriasis, rheumatoid arthritisand other inflammatory diseases.

申请人：SANTARIS PHARMA AS

地址：DK

国籍：DK

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