专利名称：Novel Structurally Designed shRNAs发明人：Gregory J. Hannon,Sihem Cheloufi申请号：US17170047申请日：20210208
公开号：US20210254064A1公开日：20210819
摘要：Provided is an improved design of shRNA based on structural mimics of miR-451precursors. These miR-451 shRNA mimics are channeled through a novel small RNAbiogenesis pathway, require AGO2 catalysis and are processed by Drosha but areindependent of DICER processing. This miRNA pathway feeds active elements only intoAgo2 because of its unique catalytic activity. These data demonstrate that this newlyidentified small RNA biogenesis pathway can be exploited in vivo to produce activemolecules.
申请人：Cold Spring Harbor Laboratory
地址：Cold Spring Harbor NY US
国籍：US
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