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8-SUBSTITUTED-2,6-METHANO-3-BENZAZOCINES AND 3-SUB

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专利名称:8-SUBSTITUTED-2,6-METHANO-3-BENZAZOCINES AND 3-SUBSTITUTEDMORPHINANES AS OPIOIDRECEPTORBINDING AGENTS

发明人:WENTLAND, Mark, P.申请号:EP01992702.9申请日:20011031公开号:EP1353909A2公开日:20031022

摘要:8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is -CH2-OH, -CH2NH2, -NHSO2CH3, and Y is O, S, NR<17> or NOH bind to opioid receptorsand are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. 8-Carboxamides, thiocarboxamides, hydroxyamidines andformamides are preferred.

申请人:Rensselaer Polytechnic Institute

地址:1223 Poples Avenue Troy, NY 12180 US

国籍:US

代理机构:Graf von Stosch, Andreas, Dr. rer. nat.

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