专利名称：Suppression of immune response via
inhibition of cathepsin S
发明人：The designation of the inventor has not yet
been filed
申请号：EP03027094.6申请日：19970422公开号：EP1400530A1公开日：20040324
摘要：Methods and products for suppressing a class II MHC-restricted immuneresponse in a mammal, or in mammalian cells, are described. The methods depend uponinhibiting invariant chain proteolysis by cathepsin S from class II MHC/invariant chaincomplexes, thereby reducing the competency of class II MHC molecules for bindingantigenic peptides, reducing presentation of antigenic peptides by class II MHCmolecules, and suppressing immune responses. The methods may be employed in thetreatment of autoimmune diseases, allergic responses, and organ or tissue graftrejection. New pharmaceutical and therapeutic compositions which are peptide-basedinhibitors of cathepsin S are also described
申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY,BRIGHAM & WOMEN'SHOSPITAL, INC.
地址：77 Massachusetts Avenue Cambridge, MA 02139 US,75 Francis Street Boston,Massachusetts 02115 US
国籍：US,US
代理机构：Hughes, Siân Victoria
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