专利名称：ASYMMETRIC HYDROFORMYLATIONS OF
PROCHIRAL OLEFINS TO CHIRALALDEHYDES IN HIGH ENANTIOMERICEXCESS
发明人：STILLE, John, K.,PARRINELLO, Giovanni申请号：EP88904854.0申请日：19880505公开号：EP0314759A1公开日：19890510
摘要： Asymmetric hydroformylation of chiral olefins can be obtained by contacting,under hydroformylation conditions, an olefin containing a prochiral center with hydrogenand carbon monoxide in the presence of a catalyst comprising a complex platinum II andN- (t-butoxycarbonyl) -2S, 4S) -4- (diphenylphosphino) -2 - [(diphenylphosphino) methyl]pyrrolidine and stannous chloride, and extracting the resulting chiral aldehyde as itforms. A preferred method the resulting chiral aldehyde of extraction consists in using aprison agent such as triethyl orthoformate, a trimethyl orthoformate, triethyl
orthoacetate, trimethyl orthoacetate a, a diethyl ketal of acetone and a dimethyl acetalof acetone used in the presence of a catalyst carrier in the solid state such as acrosslinked polystyrene.
申请人：COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
地址：P.O. Box 483, 601 South Howes, First Floor Fort Collins, Colorado 80526 US
国籍：US
代理机构：Foster, David Martyn, et al
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